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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'df1452f40d73302efd93a58e2791b6aa17135ffcdda35326bc061d4c898cfb4d' 
  AND token = 'MyfRZ0mTSIA4SnMYK7Mhzb+bS0zNHGWg9d36xDWHz68=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}