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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd0e5ce043eab06f5f4297514d0c1725e20e0ef2782644bb79045c2f38610ce68' 
  AND token = 'FZy4ha/GRoY6zKL7SwfMVTrOD6FQaVh4rRMU+peefZw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}