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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18def89a956066e369c1722f7aa7c7251a30f6052e0a087b1a4e9492204ebf3b' 
  AND token = 'WV4+oIdlMOfbBnSQynxeR7G3tTUTMfr/d3HNLnm1DiU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}