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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fa8d8af48a3d0506d461fa78483da09bfb3671a3b46cd7d027a998f9f827a0cf' 
  AND token = '2iuHqJ6z+0lc6b9/qU5Jwe2kSGFq+NHGsxHGXz42fz0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}