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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50ed7196bd17d83bb30c61e64a0fa9f2e01fe9c19269d9bb781e04439bf35b73' 
  AND token = 'IyQjO6b0D+u5V5wv2jQu6Pl4CWHJn41ZoC83LqnrOIM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}