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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3a218ad50a5d3b3de42e4f81f138185be744225fd71b21bac54df61e7ab83b55' 
  AND token = '8Xjbfe2ViOvsrK0+KLy9kxQYvnv4oygYi0ggfmVU5Q8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}