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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b43e3c7856d87b3548cd0dad312adc33e58cc01024617232327827815a8b6e5' 
  AND token = 'JBML/IdAPhVFegnCt7wLGGnUkssJN1vv9j+alLLgJ8k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}