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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49cb990ce124e2dcf1bd32bfff9d544c6dd01832c5b54529624d5c733e2e2a0a' 
  AND token = 'SRrfiT5IfYbvZFwPzswjh7beVN1r1nfe5vf6zwfWzzc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}