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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d391aad5ac2d410ce6a7e20c63d2247e94f6052493fd1da298ad34d5e79fbbb' 
  AND token = 'OrOijZaeMZ1lJnvwwo7xjRvtHvD5PxLUOnb+VOhMXNQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}