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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3cdc54757a9e47fa7106d2b7b418eb4d4cd23a2e6ff5b01eeaece806320a3da0' 
  AND token = '8AO6M/uKId3b7x5BR+sr+E/A7EBApCtMV4tuBo5ZLgw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}