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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '581b7f09b0c4c3495c19a29670d35048fbb03346f4e1560f27d7ca4dfb8104ab' 
  AND token = 'aW5j1i4gqZRmq28vaXm0dTbOUE3yBP4qHpZfu+WsrAI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}