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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22bf12ccb7ce2b27abfb9510d501cd2d7e7021fe6f62598da53dd7da082b0fb1' 
  AND token = 'jzxTcomuc/Z6er6oiAGb/o+7ux0ewPXDSGwfBbB5Rv4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}