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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0ad6e0bdeac7bf283020597d3c7a7dc34f452132d0c5fa65d0fddc0419e30a01' 
  AND token = '5Qo5BpjsmNeD2D8cd9i/p3bYqS89+VpDhDzoSRHuXU8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}