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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d66b2c48fec25a3b78e841f2dc07ff994e85349b813d3f777f35b8642b9c369' 
  AND token = '2NEHKVYsr8E6BbqufLaINedomq3WfYH5sfaPPBIaROg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}