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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16c153176304789fd8c505a75df8fc6880bf9a16cc2eb0dde11f14e20eb6e80b' 
  AND token = 'dg412gfEI+4QC9NwNhN0D//hk2Gn5c4/RJv7sSaYjfU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}