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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53aaeb05b0dd6fdbe75aa7f14cee2d49cdbea0b78acde9905e087c576abf1196' 
  AND token = 'UZuzOiqVs19mgkgQyUdOr5r19y8ga0TRGiGVyJknbic=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}