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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5c8ce55864d8cd987c5a4e9a168e26660a895db2feeeca821db725f1209de1b5' 
  AND token = 'Uitt0tjf1FDIZNSgV/yYts37hdHTQqgqEv7rY2ai+RU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}