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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53ac147fbffb2e5c30d40fedda5f29ae0483b28206383b1d27496f6d9c6ff989' 
  AND token = 'BtESrRd/3c1DF4Xj88xmsGzGpWCzQEvpGjetLtlCK04=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}