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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ff7d21f6a2cfe264f91f72f9b76b9eab9bc59b7f81ab2b37925443880c65827' 
  AND token = '25Gx9fGs469H7vGFU/ngLhktBIi6FvB2h3XNg2uSxYE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}