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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43f09bb55aa25de3636ad23b48fde24290438cbe31c7067a343e9fee5b1f5c76' 
  AND token = 'qCds4ryWCWEKSESzKYBcbfirdlZmkUexpE21RFzKvjI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}