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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a80200d95727040ca08fde86d47f9659b486e470cb5751223d5d55c810701c19' 
  AND token = 'B9R4e0aJo8FORNVIZITEJqMtMyAZYTOtSHTQLM00VTk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}