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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59a0abd62b6e5d73ad0d50039099c053bcc69a02128bae60985d78185fbb3fb4' 
  AND token = 'T8PTFGTFw5h+/Y/dZDa7NdSz4qY/SZeWdYvt3HK9xag=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}