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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '374c8195a58c872917ddad5c887cc46cf2b9dfe180f11b8c2a457af24053c028' 
  AND token = 'VZNJT6anYXNssKj7F1fsySjWq73gUYN13cQfJt9RVbQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}