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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22cbc59fd4edacca0869cbc171b5dd71ef56a9cad2f62d3708f04a51ec4c6e01' 
  AND token = 'MEQhRFw8k+z70JlmliM2HWCyoLK3NfS9j+VNKs9Q3R0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}