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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '149048336023ff6eb0f612d028019f4c3bb12a4c221e0a7a9fe9c0e661a0f8f1' 
  AND token = '/JMDgz3W8l17i2wjllhDAIevVlH6icQ/YrhOAtq5/qA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}