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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2af3a1a303180672fe27516f4e1ca29c5e8cd8e041c91bc4356416421b83c9a6' 
  AND token = 'suh5rYMGqhOFSrX85mgeKDxQjQqqvnZMm4vcFAq3nZQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}