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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0543a5d076fb1fb2bacf0cb6c23940c05b700284b62eedf0b9a506c958b43385' 
  AND token = '3b2NUp4bfeG+B/HL6FB5Ze4sCj5RKvksEafatLIhoUI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}