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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c106dc4e120b9a5eb9fa7182d8a8732ee0c0266179c1e72e3aa1aa2ab780da0' 
  AND token = '+BMKz49UJXmd6CKBh90WgkTrfjmwUgWQgarqcNIpMtw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}