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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '721b1e97871b5b3788d7e68f6c17af0b57fcb24d1b3c314e76ac668b36d0db5d' 
  AND token = 'NFff5CaGyW3d/V7Il7B49UCCjQfwQDQdWDAgtsQSBZk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}