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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'afb388d70f1f6f2dc05bda87a40785e0b9af553217f1a77b3b98270c82a356c9' 
  AND token = 'q3Y8UNo4OIUOeG06X/IP/FtDnfLmP2KNU80BN7jZWwQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}