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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '301b11a45fa99096382cab6e2a5807ace1dc44d7efd0eb4129ddd09ca07fc530' 
  AND token = 'MyE0gwnpzJibKbLAkW+jFeeEyW+Ej4aJNdkSkzXH9Bo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}