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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b43d3178b2614bc5109bf5e723f580f188140a88c2f365e3118da2ea6cfee5e1' 
  AND token = 'IPN9E0E+Yv7HX40VcgwgYjaRi0JmHX8uBW02t4qmRIM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}