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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78debf5c9af16000804df4479718c2cdf6ee40e7cc32b1feac492cb04eb6e8c4' 
  AND token = '2MPR3ckgPs66qlPJs4Yrp1w1uGhikhZHa36NztsaZIU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}