SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '597daf0029ef7bfdc9d19e800f239b01a5b2a4bd0c13472fa78647dd6e2e96ca' 
  AND token = 'itqeKN/rOh+k9inAjdQ0rrMEzGEbdbn4xAycwQHSNOA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}