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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01bd125dec51e929f2dc31dae935c916b97dc37426eb4f0bd38f675e0109f581' 
  AND token = 'CD8p7Y5HS9t8ePLApodnWV62EUXsos57S+EXts8/+uE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}