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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78c2aeca66cfca24f33881177db828883f5bf8d0c50ba4c8a7e151666ddef6bb' 
  AND token = 'hLKEGS1hTxaewAC0CU0Wm+X5prGoC+Fl8zWr2x8GjT4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}