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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46531fe7499d9df74b43c9eb8adcae2e4f7e1b0e946a821987cd77c6b3711306' 
  AND token = 'CGZbf3if6w5BtGy44lPdXbyQgWkw00BxEURVVbj75cA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}