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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '943b49efd44ed50120c3d0b5b16e658171177c1c5660c07ea497f2eb56849189' 
  AND token = 'usY0KLOsfKYG+oW1+7ALzR1LOHuRNygs1jFgQQz5nOw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}