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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b644222de02311de625e22327e48080d3216b4e9ab414086c2aa52b6e129d35' 
  AND token = 'AL6Y/AVj9JLbvBWMMdRJxTwIfExE1s1Dz1x3Leaj6IY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}