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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1de9fa81c9c4e8fe302787e6c5d929be7265b7d4f0a5f1217fd04a62b50633f0' 
  AND token = 'MoQtnDFtPOGNIElgbV7nuFteBhoG4n8ROuRt/7Q77XQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}