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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b95ae2965ff3153890abbcdc2abd80b3f1409a38dd7ab877b9c9c1e845957015' 
  AND token = 'VGEqM/Nzu1E64Kze91wt6oAf65cucmGrZCmveMlxwMM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}