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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7271ffdbdbbfdb760963ca8bf65a331245e6192274f88d79a027a486bccba0b2' 
  AND token = 'mdU1Vgcg0W9MalzpQQcOF6DS7aa2FK3SqQyiSsbX9PE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}