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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b49a9f88eaeca63fea804b2dd2d11df47673d9e05e6122e369a1c8ee6bf41aae' 
  AND token = 'acPyoL6DnY8BRuQ1GNQaBcG7y7yWIHx7GTEwwHmldiQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}