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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6674dfe1dc7260b8fb48cb68506b08b1b10b6ed5be69db18dd4acd10a678f399' 
  AND token = 'EPRg5FvOp/0BETaPkuK4A16gbPvhCYbIyOG26JZx1lg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}