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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b05278ad0d045ee72b206ca6bc2a9523e122930168f20860a16020a2b5c5268' 
  AND token = 'pC+LG6SCZBCbhq245aSeDIo42G8eDFqJP4ooF0x8x3g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}