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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e5e7e2287c80588925f4cedc92c5a9c40d3fca24f2c1e64544276f1a9bcc6191' 
  AND token = 'IyOM5D9hGAVwftMHbjSprXMwqb/CTYLxNDIgJDzVMLc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}