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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53629361dfb4536959163c882c17bbca1e7e722c4a840498385e974be6d39d1d' 
  AND token = 'mstHHEyEu4XVwsCQ2aPr/gVoK33AKn0E2qE/ujWVeIM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}