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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65bfbdb5c20f82b36605bfbb10c0d9dbb487e78c9bb2646b80db6b8c188667a4' 
  AND token = 'n4IkIxPkvYwTlVZkvAnpvcxGC+W1AyHVU20YxxiSxAo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}