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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '106ceba52f735d8f7c11817a233dd9a65ec840f6b056dcb339d3d3acb5a03420' 
  AND token = 'fve3TB1HUgC1XX2mwhIv36TlTyKRWRNc+7FH9wDAw4Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}