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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '461f0b4c297cb9d626d1b107f7da1f63559766d986a7463da065ee997c52ce55' 
  AND token = '3LAqyFy/781SqwDZ193GQHqEsplzEnkAiT5OluEqdzg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}